Global expression of AMACR transcripts predicts risk for prostate cancer – a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate
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منابع مشابه
Global expression of AMACR transcripts predicts risk for prostate cancer – a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate
BACKGROUND The high false negative rates for initial prostate biopsies refer a large number of the men for repeat biopsies each year. Therefore, biomarkers associated with high risk of the presence of malignancy in histologically benign biopsies could provide a tool to discriminate the patients who need repeat biopsy or intensive follow-up from those who do not. Here we examined the diagnostic ...
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BACKGROUND Alpha-methylacyl-CoA racemase (AMACR) is a mitochondrial and peroxisomal enzyme that is overexpressed in prostate cancer. The aim of this study was to confirm and expand the findings that the PCa risk increased in men associated with AMACR expression across various geographic regions. METHODS A systematic search of databases was carried out and other relevant articles were also ide...
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The expressions of AMACR and iNOS in prostate adenocarcinomas
BACKGROUND AND OBJECTIVE Prostate cancer is the second leading cause of death in men. The localized disease often responds to conventional therapies like androgen ablation via castration and/or administration of chemical inhibitors but advanced disease resistant to any curative therapies is still challenge for investigators. There are increasing efforts to enhance the possibility of finding pos...
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To investigate the potential relationship between sequence variants in the AMACR gene and prostate cancer risk in a Korean study cohort. We evaluated the association between 21 single nucleotide polymorphisms (SNPs) in the AMACR gene and prostate cancer risk as well as clinical characteristics (pathological stage and Gleason score) in Korean men (272 prostate cancer patients and 173 benign pros...
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ژورنال
عنوان ژورنال: BMC Urology
سال: 2016
ISSN: 1471-2490
DOI: 10.1186/s12894-016-0128-8